Journal
DRUG DISCOVERY TODAY
Volume 14, Issue 1-2, Pages 16-24Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.drudis.2008.10.002
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Funding
- National Research Foundation
- South African AIDS Vaccine Initiative
- Poliomyelitis Research Foundation
- Medical Research Council.
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Plant-produced vaccines are a much-hyped development of the past two decades, whose time to embrace reality may have finally come. Vaccines have been developed against viral, bacterial, parasite and allergenic antigens, for humans and for animals; a wide variety of plants have been used for stable transgenic expression as well as for transient expression via Agrobacterium tumefaciens and plant viral vectors. A great many products have shown significant immunogenicity; several have shown efficacy in target animals or in animal models. The realised potential of plant-produced vaccines is discussed, together with future prospects for production and registration.
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