Journal
DRUG DISCOVERY TODAY
Volume 13, Issue 9-10, Pages 379-393Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.drudis.2007.12.010
Keywords
-
Categories
Funding
- FIC NIH HHS [R01 TW 007250] Funding Source: Medline
Ask authors/readers for more resources
ATP binding cassette (ABC) drug transporters play an important role in cancer drug resistance, protection against xenobiotics, and in general in the passage of drugs through cellular and tissue barriers. This review explores how human ABC transporters modulate the pharmacological effects of various drugs, and how this predictable ADME-TOX modulation can be used during the process of drug discovery and development. We provide a description of the relevant human ABC drug transporters and review the models and assay systems that can be applied for the analysis of their expected drug interactions. The use of the in vitro, in vivo, in silico models, their combination, and the emerging clinical information are evaluated with respect to their potential application in early drug screening.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available