Journal
DRUG DISCOVERY TODAY
Volume 13, Issue 19-20, Pages 842-855Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.drudis.2008.05.007
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Chemical modification provides solutions to many of the challenges facing siRNA therapeutics. This review examines the various siRNA modifications available, including every aspect of the RNA structure and siRNA duplex architecture. The applications of chemically modified siRNA are then examined, with a focus on specificity (elimination of immune effects and hybridization-dependent off-target effects) and delivery. We also discuss improvement of nuclease stability and potency.
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