Journal
DRUG DISCOVERY TODAY
Volume 13, Issue 9-10, Pages 402-408Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.drudis.2008.02.002
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This paper describes the process for the reconstruction of a high quality human metabolic network from the genome information, the existing problems in the reconstruction and why a time consuming literature based consolidation process is needed. The reconstructed metabolic network provides a unified platform to integrate all the biological and medical information on genes, proteins, metabolites, disease, drugs and drug targets for a system level study of the relationship between metabolism and disease. System analysis of metabolic networks will help us, not only in identifying new drug targets but also in developing a system-oriented drug design strategy.
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