Journal
DRUG DEVELOPMENT RESEARCH
Volume 71, Issue 1, Pages 1-3Publisher
WILEY
DOI: 10.1002/ddr.20353
Keywords
malaria resistance; Plasmodium falciparum; Plasmodium vivax; sickle cell hemoglobin; Duffy antigen; glucose-6-phosphate dehydrogenase; glycolysis inhibitors
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New treatments for malaria are desperately needed. Malaria drug design can be assisted by knowledge on protective host genotypes. Individuals immune to severe malaria, being only mildly affected by the parasite infection, may carry alleles that provide protection from severe disease, which may provide clues for drug discovery. Lessons about protective genotypes have improved our understanding on the transmission and pathogenicity of the human immunodeficiency virus and have led to novel drug design. Similarly, clues from malaria protective genes may help in the design of new malaria therapies. Drug Dev Res 71:1-3, 2010. (C) 2009 Wiley-Liss, Inc.
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