Journal
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
Volume 38, Issue 11, Pages 1354-1359Publisher
TAYLOR & FRANCIS LTD
DOI: 10.3109/03639045.2011.650863
Keywords
Thickness; water uptake; water vapor permeability; mechanical properties; controlled release; colon
Categories
Funding
- CAPES
Ask authors/readers for more resources
High amylose and pectin were mixed at 1: 1 mass ratio and cross-linked with sodium trimetaphosphate (STMP) in alkaline medium. Films were prepared from aqueous dispersions of these cross-linked polymer blend at three different concentrations (3, 4 and 5%), by solvent casting method. Characterization of the films included thickness, surface morphology, water uptake, water vapor permeability (WVP), tensile strength measurements and enzymatic digestion. The cross-linking allowed to obtain films with improved mechanical properties and reduced WVP. The high resistance to enzymatic digestion exhibited by these films represents a promising approach to their application in the development of colon drug delivery systems.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available