4.4 Article

Optimization of acyclovir oral tablets based on gastroretention technology: Factorial design analysis and physicochemical characterization studies

Journal

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
Volume 37, Issue 7, Pages 855-867

Publisher

TAYLOR & FRANCIS LTD
DOI: 10.3109/03639045.2010.546404

Keywords

Acyclovir; floating time; gastroretentive; factorial design; HPMC; Compritol; bioavailability

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The purpose of this research was to prepare a floating drug delivery system of acyclovir. Floating matrix tablets of acyclovir were developed to prolong gastric residence time and increase its bioavailability. The tablets were prepared by direct compression technique, using polymers such as hydroxypropylmethylcellulose 4000, Compritol 888. Sodium bicarbonate was used as a gas-generating agent. A 3

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