Journal
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
Volume 36, Issue 1, Pages 56-63Publisher
TAYLOR & FRANCIS LTD
DOI: 10.3109/03639040903061355
Keywords
Controlled release; genipin; isoniazid; microspheres; polyelectrolyte complex
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Background: Microspheres of gelatin-A and kappa-carrageenan were prepared by using genipin, a naturally occurring crosslinker, and sunflower oil as reaction media. Method: The variations in the size of the microspheres formed by varying the amount of surfactant (0.33-1.0 g/g of polymer), polymer (1.5-3.0 g), and crosslinker (0.2-0.8 mmol) were studied by scanning electron microscopy. The encapsulation of isoniazid was carried out by absorption. The isoniazid content in the prepared microspheres was determined. The release characteristic of isoniazid was also studied at pH values 1.2 and 7.4 by using UV-spectrophotometer. Results: Characterization of the isoniazid-loaded microspheres was carried out by using Fourier transform infrared spectrophotometry, differential scanning calorimetry, and X-ray diffractometery.
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