Journal
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
Volume 34, Issue 2, Pages 157-163Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/03639040701484569
Keywords
rheology; petrolatum; thermorheological scans; structure; dynamic oscillatory testing
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The current study focuses on characterizing the rheological characteristics of different petrolatum grades using a controlled stress rheometer. Both steady-state flow and dynamic oscillatory tests were conducted on the petrolatums. The thermorheological scans were found to be the most informative and reproducible for this study. Significant differences in the structure were observed between the petrolatum grades. The structural differences were found to be most significant in the temperature range 25-35 degrees C. The findings from this study will help in identifying the critical parameters (for e.g., temperature, mixing) during the processing and handling of such materials, which can have a direct impact on the product rheology and performance.
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