Journal
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
Volume 34, Issue 12, Pages 1394-1405Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/03639040802130061
Keywords
SLN; NLC; LDC; drug nanocrystals; nanosuspensions; oral drug delivery; high-pressure homogenization
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Funding
- EU [CT-2004-404992]
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Solid lipid nanoparticles (SLN), nanostructured lipid carriers (NLC), and lipid-drug conjugates (LDC), commonly produced by high-pressure homogenization, are interesting vectors for oral delivery of lipophilic and, to a certain extent, hydrophilic substances. Their production can be done without the use of organic solvents. Techniques to make them a physically stable delivery system have been developed. Scaling up of the production process from lab-size to large-scale dimensions using high-pressure homogenization can be easily achieved by using a different type of homogenizer. The machines used for large-scale production often yield an even better product quality than the lab-scale types. This review article covers the methods of production, characterization, mechanisms of oral bioavailability enhancement, scale-up, final oral dosage forms, and regulatory aspects of lipid nanoparticles for oral drug delivery. It focuses mainly on high-pressure homogenization production methods.
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