Journal
DRUG DELIVERY
Volume 21, Issue 6, Pages 397-405Publisher
TAYLOR & FRANCIS LTD
DOI: 10.3109/10717544.2013.868555
Keywords
Adhesion force; aerosolization; anti-inflammatory; carrier; spray dried powder
Categories
Funding
- Higher Education Research Promotion
- National Research University Project of Thailand
- Nanotec-PSU Excellence Center on Drug Delivery System
- Office of the Higher Education Commission
- Graduate School, Prince of Songkla University
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Objective: The aim of this study was to develop a budesonide dry powder for inhalation using L-leucine and L-leucine - sieved mannitol as a carrier. Materials and methods: Budesonide and L-leucine were co-spray dried at a mass ratio of 1: 50 then blended with various mass ratios of sieved mannitol in the range of 20-80. A 2(3) factorial study was applied to investigate the effects of the spray drying variables; feed rate, aspirator setting and airflow rate on the powder characteristics. The prepared dry powders were characterized using fourier transform-infrared spectroscopy (FT-IR), differential scanning calorimetry (DSC) and ultracentrifugation. Drug contents and aerosolization properties were evaluated using high performance liquid chromatography (HPLC) and the Andersen cascade impactor (ACI), respectively. Results and discussion: There was no interaction between budesonide and L-leucine after co-spraying. The budesonide dry powders had a mass median aerodynamic diameter (MMAD) in the range of 1.9-2.2 mu m at a flow rate of 60 L/min that was suitable for pulmonary delivery. Sieved mannitol as a coarse carrier decreased the interparticulate forces between fine particles of the co-spray dried budesonide-L-leucine and resulted in a high fine particle fraction (FPF) in the range of 64-68% while the co-spray dried powder of budesonide-L-leucine had an FPF of similar to 49%. Conclusions: Blending of the co-spray dried powder with sieved mannitol significantly improved the delivery efficiency of the micronized budesonide better than the co-spray dried with L-leucine alone.
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