Journal
DRUG DELIVERY
Volume 23, Issue 3, Pages 814-817Publisher
TAYLOR & FRANCIS LTD
DOI: 10.3109/10717544.2014.917343
Keywords
Aging; antioxidant enzymes; antioxidant supplementation; diabetes mellitus; lipid peroxidation; melatonin; superoxide dismutase
Categories
Ask authors/readers for more resources
Oxidative damage has been suggested as the primary cause of aging and age-associated diseases including type 2-dependent diabetes mellitus (T2DM) and therefore there is a growing interest in exploring therapeutic potential of antioxidant agents including melatonin. In the present study, we analyzed red blood cell antioxidants and lipid peroxidation after 5mg/daily immediate-release melatonin treatment of elderly T2DM patients and healthy elderly subjects in comparison with 2mg/daily sustained-release melatonin treatment of elderly T2DM patients and healthy elderly subjects, to determine the antioxidant effect of different doses and formulations of melatonin in these groups. Our study revealed that there was no significant difference in antioxidant status of red blood cells measured by glutathione concentration and activities of GPx-1, CAT, GR, SOD-1 and MDA levels, after supplementation with 2mg-sustained release melatonin or with 5mg-immediate release melatonin, either in T2DM or in healthy elderly subjects. These results suggest that both preparations may exert similar therapeutic effect related to melatonin's action on antioxidant defense system.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available