Journal
DRUG DELIVERY
Volume 22, Issue 2, Pages 156-167Publisher
INFORMA HEALTHCARE
DOI: 10.3109/10717544.2013.853210
Keywords
Cancer chemotherapy; drug delivery; drug targeting; elastin; elastin-like polypeptides
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Funding
- Department of Science and Technology, Government of India
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Elastin-like polypeptides (ELPs) are large molecular weight biopolymers. They have been widely studied as macromolecular carriers for targeted delivery of drugs. The aim of the present article is to review the available information on ELPs (including our recent investigations), their properties, drug delivery applications to tumor sites and future perspectives. This review also provides information on the use of short synthetic ELPs for making ELP-drug conjugates, for targeted delivery of anticancer drugs. In the present review we also focus on the point that short ELPs can also be used for targeting anticancer drugs to tumor sites as they behave similar to long ELPs regarding their capacity to undergo inverse temperature transition (ITT) behavior.
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