Journal
DRUG DELIVERY
Volume 20, Issue 8, Pages 319-323Publisher
TAYLOR & FRANCIS LTD
DOI: 10.3109/10717544.2013.834420
Keywords
Baicalein; bioavailability; diethyl ether injection method; liposomes; pharmacokinetics
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Funding
- Natural Science Foundation of the Education Department of Henan Province [2011A350001]
- Scientific and Technological Project of Henan Province [122102340567]
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Long-circulating nanoliposomes (LCNs) containing Baicalein (BAI) were prepared by diethyl ether injection method in this paper. Using soybean phosphatidylcholine (SPC) and cholesterol (CHOL) as the carrier ingredients, BAI-loaded LCNs were formulated in optimized condition with encapsulation efficiency (EE) of 41.5 +/- 4.77%. The average diameter of BAI-loaded LCNs was similar to 709nm determined by dynamic light scattering (PDI 0.43). Drug storage stability study showed that BAI-loaded LCNs were highly stable in phosphate-buffered saline (PBS, pH 7.4) at 4 degrees C. Additionally, the pharmacokinetic behaviors of BAI-loaded LCNs were studied using Kunming mice as experimental animals. Parallelly, free BAI solution was studied as control. As expected, it is found that LCNs-encapsulated BAI yields greater BAI oral bioavailability with 4.52 times of free BAI. These results suggest the potential applications of LCNs for the delivery of BAI.
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