Journal
DRUG DELIVERY
Volume 16, Issue 2, Pages 108-115Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/10717540802605848
Keywords
Polyelectrolyte-drug interaction; drug delivery; drug release mechanism; swellable drug-polyelectrolyte matrices; carboxymethylcellulose
Categories
Funding
- CONICET
- SECYT-UNC
- FONCYT
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This article reports the development and delivery properties of swellable drug-polyelectrolyte matrices prepared with complexes of the acid form of carboxymethylcellulose (HCMC). Drug-polyelelectrolyte complexes (HCMC-D) were obtained by neutralization of HCMC with two model basic drugs (atenolol and metoclopramide). Characterization through FT-infrared spectroscopy, power X-ray diffraction, and DSC indicates the ionic nature of the interaction between the carboxylic groups of HCMC and the basic group of D. Matrices prepared by compacting (HCMC-D) alone or in a mixture with sodium carboxymethylcellulose were subjected to measurements of solvent up-take, dynamics of swelling, and release kinetics. Delivery rate of mixed matrices is a function of its composition and may be widely modulated. They exhibited anomalous delivery kinetics with Korsmeyer exponent n in the range 0.67-0.87. Experimental results indicate that the erosion of the hydrogel layer is the main delivery process.
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