Journal
DRUG DELIVERY
Volume 15, Issue 7, Pages 465-469Publisher
INFORMA HEALTHCARE
DOI: 10.1080/10717540802328599
Keywords
benzyl alcohol; ketoprofen; nanoemulsion; skin permeation; transdermal delivery
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We prepared a nanoemulsion system with benzyl alcohol/ ethanol/Solutol/smash HS 15 /water. Ketoprofen was used as a model drug in this study. The nanoemulsions of this system evidenced a high degree of stability. The droplet diameter did not change over a period of at least 3 months. The nanoemulsion containing 4% benzyl alcohol evidenced a permeation rate higher than was observed with the 1% and 2% nanoemulsions. Also the nanoemulsion containing 1% Solutol HS 15 provided a permeation rate higher than was seen with the 2% and 4% nanoemulsions. All ketoprofen-loaded nanoemulsions enhanced the in vitro permeation rate through mouse skins as compared to the control.
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