Journal
DRUG DELIVERY
Volume 15, Issue 3, Pages 177-183Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/10717540801952597
Keywords
magnetic nanocomposite; polymer-coated; AcrylateBased; polymer; drug release; target delivery
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Magnetic nanocomposite particles were synthesized by encapsulating nanosized magnetite with an acrylate-based cationic copolymer made of MMA, BA, and QMA and modifying with MeOPEGMA using the water replacement method. The composition of the co-polymer formulation was optimized based on zetapotential measurements and freeze-thaw stability. Electrostatic interaction between negatively charged model drug aspirin and positively charged co-polymer plays the most important role in drug loading and in vitro release studies. Drug release exhibited a biphasic profile with an initial burst release followed by a prolonged slow release, which could be potentially useful for target and controlled drug delivery.
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