Journal
DRUG AND CHEMICAL TOXICOLOGY
Volume 33, Issue 2, Pages 220-226Publisher
TAYLOR & FRANCIS LTD
DOI: 10.3109/01480540903373654
Keywords
Salidroside; reverse mutation assay; chromosomal aberration assay; mouse micronucleus assay; genotoxicity
Funding
- Nature Science Fund of Shanghai, China [09ZR1439700]
- Key Subjects of Heath Toxicology in Shanghai [08GWZX0301]
Ask authors/readers for more resources
It is reported that salidroside, the main component of a traditional Chinese medicine, Rhodiola rosea, has the efficacy of protecting Coxsackie virus impairment. As part of a safety evaluation on salidroside for use in the treatment of viral myocarditis, the present study evaluated potential genotoxicity of salidroside by using the standard battery of tests (i.e., bacterial reverse mutation assay, chromosomal aberrations assay, and mouse micronucleus assay) recommended by the State Food and Drug Administration of China. The results showed that salidroside was not genotoxic under the conditions of the reverse mutation assay, chromosomal aberrations assay, and mouse micronucleus assay conditions. The anticipated clinical dose seems to be smaller than the doses administered in the genotoxicity assays. With confirmation from further toxicity studies, salidroside would hopefully prove to be a safe anti-Coxsackie virus agent.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
© Peeref 2019-2024. All rights reserved.