Journal
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
Volume 148, Issue -, Pages 252-261Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.jphotobiol.2015.04.014
Keywords
Benzimidazole; Transition metal complex; Crystal structure; DNA-binding property; Antioxidant activity
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Funding
- National Natural Science Foundation of China [21367017]
- Fundamental Research Funds for the Gansu Province Universities [212086]
- Natural Science Foundation of Gansu Province [1212RJZA037]
- 'Qing Lan' Talent Engineering Funds for Lanzhou Jiaotong University
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A V-shaped ligand 1,3-bis(1-ethylbenzimidazol-2-yl)-2-thiapropane (bebt) and its transition metal complexes, [Mn(bebt)(pic)(2)].CH3OH (plc = picrate) 1, [Co(bebt)(2)](pic)(2) 2 and [Cu(bebt)(2)](pic)(2).2DMF 3, have been synthesized and characterized. The coordinate forms of complexes 1 and 2 are basically alike, which can be described as six-coordinated distorted octahedron. The geometric structure around Cu(II) atom can be described as distorted tetrahedral in complex 3. The DNA-binding properties of the ligand bebt and complexes have been investigated by electronic absorption, fluorescence, and viscosity measurements. The results suggest that bebt and complexes bind to DNA via an intercalative binding mode and the order of the binding affinity is 1 < 2 < 3 < bebt. The possible relations between the structure and DNA-binding properties are also discussed. Moreover, the complex 3 possess significant antioxidant activity against superoxide and hydroxyl radicals, and the scavenging effects of it are stronger than standard mannitol and vitamin C. (C) 2015 Elsevier B.V. All rights reserved.
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