Journal
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
Volume 142, Issue -, Pages 77-85Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.jphotobiol.2014.11.008
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Funding
- State Key Laboratory of Coordination Chemistry of Nanjing University
- Nanjing Forestry University
- Priority Academic Program Development of Jiangsu Higher Education Institutions, College and University Graduate Research Innovation Project of Jiangsu Province [CXLX13_517]
- University Science Research Project of Jiangsu Province [13KJB220006]
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The first chiral trinuclear iron(III) complex [Fe-3(mu(3)-O)(L)(6)(CH3OH)(2)(CH3O)]-H2O (2) of a natural rosin product dehydroabietic acid (HL, 1) was synthesized and fully characterized. The interactions of 1 and 2 with salmon sperm DNA were investigated by viscosity measurements, UV, fluorescence and circular dichroism (CD) spectroscopic techniques. Absorption spectral (K-b = 1.30 x 10(5) M-1 (1), 1.40 x 10(5) M-1(2)), emission spectral (K-sv = 1.19 x 10(4) M-1 (1), 1.79 x 10(4) M-1 (2)) and viscosity measurements reveal that 1 and 2 interacted with DNA through intercalation and 2 exhibited a slight higher DNA binding ability. The Stern-Volmer quenching constant (K-sv) and corresponding thermodynamic parameters (Delta G, Delta H and Delta S) of the binding processes were determined. The negative Delta H and Delta G values indicate that the binding reactions were exothermic and spontaneous. 1 and 2 were also screened for their cytotoxic ability and 1 demonstrated higher growth inhibition of the selected cancer cells at concentrations of 25 mu M and 50 mu M, this result was not identical with their DNA binding ability order. Thus, the involvement of Fe(III) centers had positive effect on DNA binding ability and negative effect on cytotoxicity. (C) 2014 Elsevier B.V. All rights reserved.
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