Journal
DRUG AND ALCOHOL DEPENDENCE
Volume 133, Issue 2, Pages 376-382Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.drugalcdep.2013.06.024
Keywords
Buprenorphine abuse; Treatment; Republic of Georgia
Categories
Funding
- National Institute on Drug Abuse [R21-DA-026754, U10 DA-13043, KO5 DA-17009]
- Reckitt Benckiser Pharmaceuticals Inc.
Ask authors/readers for more resources
Aims: Determine the extent to which buprenorphine injectors continue treatment with buprenorphinenaloxone or methadone, and the impact of these treatments on substance use and HIV risk in the Republic of Georgia. Methods: Randomized controlled 12-week trial of daily-observed methadone or buprenorphine-naloxone followed by a dose taper, referral to ongoing treatment, and follow-up at week 20 at the Uranti Clinic in Tbilisi, Republic of Georgia. Eighty consenting treatment-seeking individuals (40/group) aged 25 and above who met ICD-10 criteria for opioid dependence with physiologic features and reported injecting buprenorphine 10 or more times in the past 30 days. Opioid use according to urine tests and self-reports, treatment retention, and HIV risk behavior as determined by the Risk Assessment Battery. Results: Mean age of participants was 33.7 (SD5.7), 4 were female, mean history of opioid injection use was 5.8 years (SD4.6), none were HIV+ at intake or at the 12-week assessment and 73.4% were HCV+. Sixty-eight participants (85%) completed the 12-week medication phase (33 from methadone and 35 from buprenorphine/naloxone group); 37 (46%) were in treatment at the 20-week follow-up (21 from methadone and 16 from the buprenorphine/naloxone group). In both study arms, treatment resulted in a marked reduction in unprescribed buprenorphine, other opioid use, and HIV injecting risk behavior with no clinically significant differences between the two treatment arms. Conclusions: Daily observed methadone or buprenorphine-naloxone are effective treatments for nonmedical buprenorphine and other opioid use in the Republic of Georgia and likely to be useful for preventing HIV infection. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available