Journal
DRUG AND ALCOHOL DEPENDENCE
Volume 123, Issue 1-3, Pages 264-268Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.drugalcdep.2011.11.002
Keywords
Reinstatement; Morphine; Intra-venous self-administration; Drug-seeking; MGluR5; Opiates; Relapse
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Funding
- National Health & Medical Research Council of Australia [566736]
- Pratt/Besen Foundations
- Victorian Government's Operational Infrastructure Support Program
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The mGlu5 receptor (mGluR5) has been implicated in the rewarding effect of various drugs of abuse and drug-seeking behaviour. In the present study we investigated the impact of antagonism of mGluR5 with the selective negative allosteric, modulator 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine (MTEP) on operant self-administration of morphine as well as cue-induced drug-seeking in adult CD1 mice. Administration of MTEP (20 mg/kg, i.p.) attenuated operant responding for morphine (0.1 mg/kg/infusion) and cue-induced morphine-seeking after a period of forced abstinence. Collectively, these data implicate mGluR5 in the reinforcing effects of opiates and support the proposition that mGluR5 is a potential therapeutic target for treatment of drug addiction. (c) 2011 Elsevier Ireland Ltd. All rights reserved.
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