Journal
DRUG AND ALCOHOL DEPENDENCE
Volume 115, Issue 1-2, Pages 43-50Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.drugalcdep.2010.10.017
Keywords
Adolescent; Substance use disorder; fMRI; Response inhibition; Incentive; Antisaccade
Categories
Funding
- National Institute on Alcohol Abuse and Alcoholism [K02 AA018195, R01 AA014357, R21 AA017128, R21 AA016272, K02AA00291, R21 AA017312]
- NIDA [P50DA05605, K01 DA018698]
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Effective response inhibition is a key component of recovery from addiction. Some research suggests that response inhibition can be enhanced through reward contingencies. We examined the effect of monetary incentive on response inhibition among adolescents with and without substance use disorder (SLID) using a fast event-related fMRI antisaccade reward task. The fMRI task permits investigation of how reward (monetary incentive) might modulate inhibitory control during three task phases: cue presentation (reward or neutral trial), response preparation, and response execution. Adolescents with lifetime SUD (n = 12; 100% marijuana use disorder) were gender and age-matched to healthy controls (n = 12). Monetary incentive facilitated inhibitory control for SUD adolescents: for healthy controls, the difference in error rate for neutral and reward trials was not significant. There were no significant differences in behavioral performance between groups across reward and neutral trials, however, group differences in regional brain activation were identified. During the response preparation phase of reward trials, SUD adolescents, compared to controls, showed increased activation of prefrontal and oculomotor control (e.g., frontal eye field) areas, brain regions that have been associated with effective response inhibition. Results indicate differences in brain activation between SUD and control youth when preparing to inhibit a prepotent response in the context of reward, and support a possible role for incentives in enhancing response inhibition among youth with SUD. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
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