Journal
DRUG AND ALCOHOL DEPENDENCE
Volume 111, Issue 3, Pages 191-199Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.drugalcdep.2010.04.012
Keywords
Cocaine; MRI; Brain morphometry; Tensor based morphometry; Jacobian determinant; Unbiased atlas; Nonlinear registration
Categories
Funding
- NIBIB/NIH [EB002095]
- NCRR/NIH [S10 RR19186, S10 RR19186-01(PAN)]
- NIDA/NIH [P50-DA009262, P50-DA0092629]
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Magnetic resonance imaging (MRI) was performed in cocaine-dependent subjects to determine the structural changes in brain compared to non-drug using controls Cocaine dependent subjects and controls were carefully screened to rule out brain pathology of undetermined origin Magnetic resonance Images were analyzed using tensor-based morphometry (TBM) and voxel-based morphometry (VBM) without and with modulation to adjust for volume changes during normalization For TBM analysis unbiased atlases were generated using two different Inverse consistent and diffeomorphic nonlinear registration techniques Two different control groups were used for generating unbiased atlases Independent of the nonlinear registration technique and normal cohorts used for creating the unbiased atlases our analysis failed to detect any statistically significant effect of cocaine on brain volumes These results show that cocaine-dependent subjects do not show differences in regional brain volumes compared to non-drug using controls (C) 2010 Elsevier Ireland Ltd All rights reserved
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