Journal
DOSE-RESPONSE
Volume 11, Issue 4, Pages 469-479Publisher
INT DOSE-RESPONSE SOC
DOI: 10.2203/dose-response.13-004.Calabrese
Keywords
sinusitis; radiotherapy; dose response; x-rays; history of medicine; inflammation
Funding
- U.S. Air Force
- ExxonMobil Foundation
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The aim of this paper is to assess the historical role of radiotherapy in the treatment of sinus infections. This assessment involved a literature-based review of how radiotherapy was used to treat sinus infections in the first half of the 20th century. Low doses of x-rays were used with considerable success to treat nearly 3,000 patients of sinus infection in a span of 12 years with these cases being reported in leading medical journals as case studies. The mechanism of x-ray induced reduction of inflammation and increased tissue repair is uncertain but appears to be related to the development of a multifactorial and integrative anti-inflammatory phenotype.
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