Journal
DNA RESEARCH
Volume 21, Issue 5, Pages 469-480Publisher
OXFORD UNIV PRESS
DOI: 10.1093/dnares/dsu013
Keywords
commensal microbiota; correlation analysis; gut ecosystem; metabolite; prebiotics
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Funding
- Ministry of Education, Culture, Sports, Science and Technology of Japan [24380072, 21390155, 24117524, 20113003, 24658129]
- Institute for Fermentation, Osaka
- Mishima Kaiun Memorial Foundation
- Takeda Science Foundation
- Uehara Memorial Foundation
- Grants-in-Aid for Scientific Research [24117524, 25513012, 21390155, 24658129, 20113003] Funding Source: KAKEN
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Fructooligosaccharide (FOS), a prebiotic well known for its health-promoting properties, can improve the human gut ecosystem most likely through changes in its microbial composition. However, the detailed mechanism(s) of action of FOS in the modulation of the gut ecosystem remain(s) obscure. Traditional methods of profiling microbes and metabolites could barely show any significant features due to the existence of large interindividual differences, but our novel microbe-metabolite correlation approach, combined with faecal immunoglobulin A (IgA) measurements, has revealed that the induction of mucosal IgA by FOS supplementation correlated with the presence of specific bacteria. Furthermore, the metabolic dynamics of butyrate, (L)-phenylalanine, (L)-lysine and tyramine were positively correlated with that of these bacteria and IgA production, whereas p-cresol was negatively correlated. Taken together, our focused intraindividual analysis with omics approaches is a powerful strategy for uncovering the gut molecular network and could provide a new vista for understanding the human gut ecosystem.
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