Journal
DNA REPAIR
Volume 71, Issue -, Pages 43-55Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.dnarep.2018.08.006
Keywords
DNA damage; Nucleotide excision repair; Transcription-coupled nucleotide excision repair; Cockayne syndrome; Lesion recognition; RNA polymerase II; Transcriptional arrest
Categories
Funding
- National Institutes of Health [R01 GM102362]
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM102362] Funding Source: NIH RePORTER
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Eukaryotic transcription-coupled nucleotide excision repair (TC-NER) is a pathway that removes DNA lesions capable of blocking RNA polymerase II (Pol II) transcription from the template strand. This process is initiated by lesion-arrested Pol II and the recruitment of Cockayne Syndrome B protein (CSB). In this review, we will focus on the lesion recognition steps of eukaryotic TC-NER and summarize the recent research progress toward understanding the structural basis of Pol II-mediated lesion recognition and Pol II-CSB interactions. We will discuss the roles of CSB in both TC-NER initiation and transcription elongation. Finally, we propose an updated model of tripartite lesion recognition and verification for TC-NER in which CSB ensures Pol II-mediated recognition of DNA lesions for TC-NER.
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