Journal
DNA REPAIR
Volume 71, Issue -, Pages 82-86Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.dnarep.2018.08.010
Keywords
H3K36me3; MSH6; Replication timing; Actively-transcribed genes; Transcription-coupled repair; Mutation frequency
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Funding
- National Institutes of Health [GM112702, CA192003]
- National Natural Science Foundation of China [31570814, 81630077]
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DNA mismatch repair (MMR) is an evolutionally conserved genome maintenance pathway and is well known for its role in maintaining replication fidelity by correcting biosynthetic errors generated during DNA replication. However, recent studies have shown that MMR preferentially protects actively transcribed genes from mutation during both DNA replication and transcription. This review describes the recent discoveries in this area. Potential mechanisms by which MMR safeguards actively transcribed genes are also discussed.
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