Journal
DNA REPAIR
Volume 19, Issue -, Pages 143-151Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.dnarep.2014.03.017
Keywords
DNA structure; DNA replication; DNA repair; Transcription; Genetic instability
Categories
Funding
- NIH/NCI [CA093729]
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Repetitive genomic sequences can adopt a number of alternative DNA structures that differ from the canonical B-form duplex (i.e. non-B DNA). These non-B DNA-forming sequences have been shown to have many important biological functions related to DNA metabolic processes; for example, they may have regulatory roles in DNA transcription and replication. In addition to these regulatory functions, non-B DNA can stimulate genetic instability in the presence or absence of DNA damage, via replication-dependent and/or replication-independent pathways. This review focuses on the interactions of non-B DNA conformations with DNA repair proteins and how these interactions impact genetic instability. (C) 2014 Elsevier B.V. All rights reserved.
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