Journal
DNA REPAIR
Volume 19, Issue -, Pages 163-168Publisher
ELSEVIER
DOI: 10.1016/j.dnarep.2014.03.015
Keywords
DSB; DNA repair; DDR; Heterochromatin; HP1; KAP1
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Chromosomal translocations are a hallmark of cancer cells and they represent a major cause of tumorigenesis. To avoid chromosomal translocations, faithful repair of DNA double strand breaks (DSBs) has to be ensured in the context of high ordered chromatin structure. However, chromatin compaction is proposed to represent a barrier for DSB repair. Here we review the different mechanisms cells use to alleviate the heterochromatic barrier for DNA repair. At the same time, we discuss the activating role of heterochromatin-associated proteins in this process, therefore proposing that chromatin structure, more than being a simple barrier, is a key modulator of DNA repair. (C) 2014 Elsevier B.V. All rights reserved.
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