Journal
DNA REPAIR
Volume 19, Issue -, Pages 199-213Publisher
ELSEVIER
DOI: 10.1016/j.dnarep.2014.03.009
Keywords
DNA repair capacity; Multiplex assays; Personalized disease prevention and treatment
Categories
Funding
- NCI NIH HHS [P30 CA014051] Funding Source: Medline
- NIEHS NIH HHS [P30 ES002109, DP1 ES022576] Funding Source: Medline
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Why does a constant barrage of DNA damage lead to disease in some individuals, while others remain healthy? This article surveys current work addressing the implications of inter-individual variation in DNA repair capacity for human health, and discusses the status of DNA repair assays as potential clinical tools for personalized prevention or treatment of disease. In particular, we highlight research showing that there are significant inter-individual variations in DNA repair capacity (DRC), and that measuring these differences provides important biological insight regarding disease susceptibility and cancer treatment efficacy. We emphasize work showing that it is important to measure repair capacity in multiple pathways, and that functional assays are required to fill a gap left by genome wide association studies, global gene expression and proteomics. Finally, we discuss research that will be needed to overcome barriers that currently limit the use of DNA repair assays in the clinic. (C) 2014 Elsevier B.V. All rights reserved.
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