Journal
DNA REPAIR
Volume 10, Issue 10, Pages 1060-1065Publisher
ELSEVIER
DOI: 10.1016/j.dnarep.2011.07.009
Keywords
DNA replication; Mre11; Rad51
Categories
Funding
- Cancer Research, UK
- European Research Council (ERC) [206281]
- Lister Institute of Preventive Medicine
- EMBO
- European Research Council (ERC) [206281] Funding Source: European Research Council (ERC)
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Homologous recombination (HR) is required for faithful repair of double strand breaks (DSBs)and is believed to be important for DNA replication under stressful conditions in unicellular organisms. However, its role during DNA replication in high eukaryotes has always been elusive. In particular, due to the essential nature of its main players it has been difficult to dissect the direct role of HR in DNA replication. Recent studies revealed that some key HR factors such as Rad51 and BRCA2 play unexpected functions during DNA replication by protecting nascent DNA from Mre11 mediated degradation, which takes place at stalled replication forks. These novel functions appear to be essential to ensure smooth progression of DNA replication and to promote maintenance of genome stability. (C) 2011 Elsevier B.V. All rights reserved.
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