Journal
DNA REPAIR
Volume 10, Issue 7, Pages 730-733Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.dnarep.2011.04.023
Keywords
DNA polymerase delta; DNA polymerase epsilon; DNA polymerase kappa; Unscheduled DNA synthesis; Xeroderma pigmentosum
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Funding
- Medical Research Council [G0801130B] Funding Source: researchfish
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The late steps of nucleotide excision repair, following incisions to remove the damaged section of DNA, comprise repair synthesis and ligation. In vitro and in vivo studies have shown the size of the repaired patch to be about 30 nucleotides. In vitro studies implicated the replicative polymerases in repair synthesis, but recent in vivo data have shown that several DNA polymerases and ligases are involved in these steps in human cells. (C) 2011 Elsevier B.V. All rights reserved.
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