Journal
DNA REPAIR
Volume 9, Issue 12, Pages 1256-1263Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.dnarep.2010.09.018
Keywords
DNA repair; DNA double strand breaks; Non-homologous end-joining; Homologous recombination
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The repair of DNA double strand breaks (dsb) is important for maintaining the physical and genetic integrity of the genome. Moreover, in humans it is associated with the prevention of diseases such as immune deficiencies and cancer. This review briefly explores the fundamental strategies for repairing dsb, examines how cells maximize the fidelity of dsb repair in the cell cycle and discusses the requirements for dsb repair in the context of chromatin. (C) 2010 Elsevier B.V. All rights reserved.
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