Journal
DNA REPAIR
Volume 9, Issue 2, Pages 161-168Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.dnarep.2009.11.010
Keywords
DNA mismatch repair; Msh6; UVB; Apoptosis; p53; Caspase 2; Centrosome
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Funding
- Canadian Institutes of Health Research
- National Cancer Institute of Canada
- Alberta Heritage Foundation
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Many studies have shown that DNA mismatch repair (MMR) has a role beyond that of repair in response to several types of DNA damage, including ultraviolet radiation (UV). We have demonstrated previously that the MMR-dependent component of UVB-induced apoptosis is integral to the suppression of UVB-induced tumorigenesis. Here we demonstrate that Msh6-dependent UVB-induced apoptotic pathway is both activated via the mitochondria and p53-independent. In addition, we have shown for the first time that caspase 2, an initiator caspase, localizes to the centrosomes in mitotic primary mouse embryonic fibroblasts, irrespective of MMR status and UVB treatment. (C) 2009 Elsevier B.V. All rights reserved.
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