Journal
DNA REPAIR
Volume 8, Issue 9, Pages 1068-1076Publisher
ELSEVIER
DOI: 10.1016/j.dnarep.2009.04.007
Keywords
Homologous recombination; Foci; DNA double-strand break repair; Saccharomyces cerevisiae; Mammalian
Categories
Funding
- Danish Agency for Science, Technology and Innovation
- Villum Kann Rasmussen Foundation
- NIH [GM50237, GM67055]
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Genome integrity is frequently challenged by DNA lesions from both endogenous and exogenous sources. A single DNA double-strand break (DSB) is lethal if unrepaired and may lead to loss of heterozygosity, mutations, deletions, genomic rearrangements and chromosome loss if repaired improperly. Such genetic alterations are the main causes of cancer and other genetic diseases. Consequently, DNA double-strand break repair (DSBR) is an important process in all living organisms. DSBR is also the driving mechanism in most strategies of gene targeting, which has applications in both genetic and clinical research. Here we review the cell biological response to DSBs in mitotically growing cells with an emphasis on homologous recombination pathways in yeast Saccharomyces cerevisiae and in mammalian cells. (C) 2009 Elsevier B.V. All rights reserved
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