Journal
DNA REPAIR
Volume 8, Issue 4, Pages 517-524Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.dnarep.2009.01.010
Keywords
Ubiquitin; SUMO; STUbL; Proteasome; Degradation; SUMO-interaction motif; Ubiquitin ligase; DNA repair; Genome stability
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Funding
- NIH [GM068608, GM081840, CA104660]
- Boehringer Ingelheim Foundation (BIF)
- Scripps Cell Cycle Groups
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Post-translational modification of the cell's proteome by ubiquitin and ubiquitin-like proteins provides dynamic functional regulation. Ubiquitin and SUMO are well-studied post-translational modifiers that typically impart distinct effects on their targets. The recent discovery that modification by SUMO can target proteins for ubiquitination and proteasomal degradation sets a new paradigm in the field, and offers insights into the roles of SUMO and ubiquitin in genome stability. (C) 2009 Elsevier B.V. All rights reserved.
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