Journal
DNA REPAIR
Volume 8, Issue 4, Pages 461-469Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.dnarep.2009.01.006
Keywords
DNA damage tolerance; Translesion synthesis; PCNA; Ubiquitin; SUMO; RAD6 pathway; Rad18; RPA; DNA; Ubc9; Siz1
Categories
Funding
- Cancer Research UK
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Modifications of the eukaryotic sliding clamp, proliferating cell nuclear antigen (PCNA), by ubiquitin and the ubiquitin-related protein SUMO, are well known to influence the choice of pathways for the processing of DNA lesions during replication. Over the past few years, significant progress has been made not only with respect to the molecular consequences that each of the modifications has for the properties of PCNA, but also in terms of the cellular signals that elicit the ubiquitylation or sumoylation of PCNA in the appropriate situations. This review will discuss the regulatory mechanisms that control PCNA modifications, emphasizing the important role of the DNA template on which PCNA acts in activating the relevant ubiquitin and SUMO conjugation factors, and pointing out similarities as well as some interesting variations among different organisms in the regulation of PCNA modifications. (C) 2009 Elsevier B.V. All rights reserved.
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