Journal
DNA REPAIR
Volume 8, Issue 4, Pages 525-535Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.dnarep.2009.01.014
Keywords
Ubiquitin; RING finger; Ubox; Ubiquitin ligase; Ligase structure; DNA repair
Categories
Funding
- EU-TMR
- EU-NOE Rubicon
- [KWF-NKI-2006-3476]
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Ubiquitin conjugation plays critical roles in virtually all DNA repair pathways. This review provides an overview of the known multi-domain RING/Ubox E3 ligases and their domain structures. An analysis of known RING/Ubox X-ray and NMR structures leads to a discussion of the effects of dimerization. Structural and mechanistic data relating to the E3 ligase preferences for E2 interaction and chain-type specificity are reviewed and the role of the E3 ligases in regulation of the repair pathways is discussed. (C) 2009 Elsevier BY. All rights reserved.
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