Journal
DNA REPAIR
Volume 7, Issue 7, Pages 1077-1086Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.dnarep.2008.03.009
Keywords
PARP-1; DNA repair; base excision repair; single-strand break; neurological disorders
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Funding
- Medical Research Council [G0700730] Funding Source: Medline
- MRC [G0700730] Funding Source: UKRI
- Medical Research Council [G0700730] Funding Source: researchfish
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Poly(ADP-ribose) polymerase-1 (PARP-1) is one of the most abundant proteins within mammalian cells. First described more than 45 years ago, PARP-1 has been the subject of many studies and was shown to be involved in multiple aspects of cellular metabolism. Despite many interesting studies that implicate PARP-1 in transcription, chromatin remodelling, apoptosis, DNA repair and several neurological disorders, its precise role is still unclear. This review will discuss the role of PARP-1 in DNA repair and propose a model whereby PARP-1 operates as a modulator of base excision repair capacity. (C) 2008 Elsevier B.V. All rights reserved.
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