Journal
DNA REPAIR
Volume 7, Issue 11, Pages 1776-1786Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.dnarep.2008.07.017
Keywords
Werner syndrome; RecQ helicase; Human cell culture; Replication stress; Damage tolerance
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Funding
- NCI [P01 CA77872, P20 CA103728-04, 000618167]
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Congenital deficiency in the WRN protein, a member of the human RecQ helicase family, gives rise to Werner syndrome, a genetic instability and cancer predisposition disorder with features of premature aging. Cellular roles of WRN are not fully elucidated. WRN has been implicated in telomere maintenance, homologous recombination, DNA repair, and other processes. Here I review the available data that directly address the role of WRN in preserving DNA integrity during replication and propose that WRN can function in coordinating replication fork progression with replication stress-induced fork remodeling. I further discuss this role of WRN within the contexts of damage tolerance group of regulatory pathways, and redundancy and cooperation with other RecQ helicases. Published by Elsevier B.V
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