Journal
JOURNAL OF PHARMACEUTICAL SCIENCES
Volume 104, Issue 3, Pages 930-941Publisher
WILEY-BLACKWELL
DOI: 10.1002/jps.24316
Keywords
Therapeutic antibody; immunotherapy; glycosylation; cancer; immunology; targeted drug delivery; conjugation; biotechnology
Ask authors/readers for more resources
Monoclonal antibodies have demonstrated enormous potential as new classes of drugs that confer great benefits to patients, and more than 40 therapeutic antibodies have already been approved for clinical use. In particular, the past 5 years might be recognized as the period guiding the new era for engineered antibodies, with the successful approval of numerous antibody-drug conjugates, bispecific antibodies, and glyco-engineered antibodies for clinical applications. In this review, we summarize the development of antibody engineering technologies that are proving their concepts in the clinic, mainly focusing on the latest trends in defucosylated antibody technologies. (c) 2015 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci 104:930-941, 2015
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available