Journal
DISEASE MODELS & MECHANISMS
Volume 3, Issue 5-6, Pages 281-289Publisher
COMPANY BIOLOGISTS LTD
DOI: 10.1242/dmm.002790
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Funding
- Commission of the European Community [LSHG-CT-2006-037811]
- National Institutes of Health [CA089713]
- Ellison Medical Foundation
- MRC [MC_U142684171] Funding Source: UKRI
- Medical Research Council [MC_U142684171] Funding Source: researchfish
- NATIONAL CANCER INSTITUTE [R01CA089713] Funding Source: NIH RePORTER
- NATIONAL CENTER FOR RESEARCH RESOURCES [R13RR017436] Funding Source: NIH RePORTER
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A major challenge of the post-genomic era is coding phenotype data from humans and model organisms such as the mouse, to permit the meaningful translation of phenotype descriptions between species. This ability is essential if we are to facilitate phenotype-driven gene function discovery and empower comparative pathobiology. Here, we review the current state of the art for phenotype and disease description in mice and humans, and discuss ways in which the semantic gap between coding systems might be bridged to facilitate the discovery and exploitation of new mouse models of human diseases.
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