Journal
DISEASE MARKERS
Volume 2013, Issue -, Pages -Publisher
HINDAWI LTD
DOI: 10.1155/2013/948569
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Funding
- Australian Dental Research Foundation
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This study profiled the local and systemic inflammatory responses to experimentally induced gingivitis. Eight females participated in a 21-day experimental gingivitis model followed by a 14-day resolution phase. Bleeding on probing and plaque index scores were assessed before, during, and after resolution of gingival inflammation, and samples of saliva, GCF, and plasma were collected. Samples were assessed for biomarkers of inflammation using the BioPlex platform and ELISA. There were no significant changes in GCF levels of cytokines during the experimental phase; however, individual variability in cytokine profiles was noted. During resolution, mean GCF levels of IL-2, IL-6, and TNF-alpha decreased and were significantly lower than baseline levels (P = 0.003, P - 0.025, and P - 0.007, resp.). Furthermore, changes in GCF levels of IL-2, IL-6, and TNF-alpha during resolution correlated with changes in plaque index scores (P = 0.88, P = 0.004; P = 0.72, P = 0.042; P = 0.79, P = 0.019, resp.). Plasma levels of sICAM-1 increased significantly during the experimental phase (P = 0.002) and remained elevated and significantly higher than baseline levels during resolution (P < 0.001). These results support the concept that gingivitis adds to the systemic inflammatory burden of an individual.
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