Journal
JOURNAL OF PERINATOLOGY
Volume 35, Issue 8, Pages 566-569Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/jp.2015.17
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Funding
- NIH T32 Grant [5T32HD055172-05]
- Washington University Institute of Clinical and Translational Sciences [UL1TR000448]
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OBJECTIVE: To determine if the use of a sex-specific standard to define small-for-gestational age (SGA) will improve prediction of stillbirth. STUDY DESIGN: We performed a retrospective cohort study of singleton pregnancies excluding anomalies, aneuploidy, undocumented fetal sex or birthweight. SGA was defined as birthweight < 10th percentile by the non-sex-specific and sex-specific Alexander standards. The association between SGA and stillbirth using these standards was assessed using logistic regression. RESULT: Among 57 170 pregnancies meeting inclusion criteria, 319 (0.6%) pregnancies were complicated by stillbirth. The area under the receiver operating characteristic curve for the prediction of stillbirth was greater for the sex-specific compared to the non-sex-specific standard (0.83 vs 0.72, P < 0.001). CONCLUSION: Our findings suggest adoption of a sex-specific standard for diagnosis of SGA as it is more discriminative in identifying the SGA fetus at risk for stillbirth.
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