Journal
DIGESTIVE DISEASES AND SCIENCES
Volume 55, Issue 11, Pages 3132-3137Publisher
SPRINGER
DOI: 10.1007/s10620-010-1154-0
Keywords
Cohort study; Gastric cancer; Mass screening; Helicobacter pylori; Atrophic gastritis
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Funding
- Ministry of Education, Science, Sports and Culture of Japan [06454543]
- Ministry of Health, Labor, and Welfare, Japan [H13-9]
- Grants-in-Aid for Scientific Research [06454543] Funding Source: KAKEN
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Though gastric cancer screening by X-ray examination has been confirmed to be effective for reducing gastric cancer mortality, decreases in efficiency have been pointed out. Establishment of an effective screening system, focusing on high-risk status such as Helicobacter pylori infection and atrophic gastritis, is desirable. To date, combined use of serum anti-Helicobacter pylori antibodies and pepsinogen measurement has been assessed prospectively in participants in opportunistic and workplace health check-ups; however, there are no reports of population-based cohort study. To clarify the population-based risk of Helicobacter pylori infection and atrophic gastritis for gastric cancer, a cohort study was conducted in rural towns in Kyoto Prefecture. Subjects were 1,011 males and 1,848 females recruited in a health check-up in 1987. Their serum was examined for anti-Helicobacter pylori antibodies and pepsinogen I and II. Gastric cancer cases were assessed from the cancer registry of those towns. Up to the end of 1996, 33 males and 28 females developed gastric cancer. A sex- and age-adjusted hazard ratio was calculated by Cox's proportional model. Helicobacter pylori infection increased the risk of gastric cancer even when the subjects had no atrophy (hazard ratio = 4.20; 95% confidence interval, 0.96-18.40). The risk increased further when they had both Helicobacter pylori infection and atrophy (hazard ratio = 11.23; 95% confidence interval, 2.71-46.51). Subjects with atrophy but negative for anti-Helicobacter pylori antibodies had the highest risk (hazard ratio = 14.81; 95% confidence interval, 2.47-88.80). A high-risk group for gastric cancer can be selected by serological prescreening.
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