Journal
DIGESTIVE DISEASES AND SCIENCES
Volume 53, Issue 12, Pages 3158-3169Publisher
SPRINGER
DOI: 10.1007/s10620-008-0279-x
Keywords
Eosinophils; Intestinal ischemia; Mast cells; NOS; Reperfusion; VIP
Categories
Funding
- Swedish Medical Research Council [K2005-72X-13406-06A]
- Ihre and Crafoord Foundations
- Royal Physiographic Society
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Intestinal ischemia as well as mastocytosis occur in patients with inflammatory bowel disease and irritable bowel syndrome. Our aim was to clarify how ischemia with reperfusion (I/R) affects the structure, enteric neurons, and immune cells in the colon. Rats were subjected to colon ischemia for 1 h and reperfused for 1 day up to 20 weeks; sham-operated rats were used as controls. No structural remodeling of the intestinal segment was detected after I/R. The number and distribution of eosinophils were not affected by I/R. Local areas containing numerous mast cells were detected in the muscle layers, the serosa, and in and around the myenteric ganglia 4-20 weeks post ischemia. It was notable that myenteric ganglionic formations within mast-cell-rich areas virtually lacked neurons. Mast cells were rarely found in controls. In conclusion, I/R of the colon attracts mast cells, and death of myenteric neurons occurs in such locations.
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