Journal
DIFFERENTIATION
Volume 76, Issue 6, Pages 641-659Publisher
ELSEVIER SCI LTD
DOI: 10.1111/j.1432-0436.2008.00277.x
Keywords
prostate development; androgen receptor; Hox genes; Nkx3.1; FoxA1; Notch; Fgf10; Shh; Bmp4; Bmp7; TgfB1; Wnt genes
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Funding
- NIDDK NIH HHS [DK40890, DK09873, F31 DK009653, DK09653, R01 DK040890, F32 DK009873, R01 DK040890-19] Funding Source: Medline
- NIEHS NIH HHS [ES12282] Funding Source: Medline
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Prostate gland development is a complex process that involves coordination of multiple signaling pathways including endocrine, paracrine, autocrine, juxtacrine and transcription factors. To put this into proper context, the present manuscript will begin with a brief overview of the stages of prostate development and a summary of androgenic signaling in the developing prostate, which is essential for prostate formation. This will be followed by a detailed description of other transcription factors and secreted morphogens directly involved in prostate formation and branching morphogenesis. Except where otherwise indicated, results from rodent models will be presented since studies that examine molecular signaling in the developing human prostate gland are sparse at the present time.
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