Journal
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
Volume 79, Issue 4, Pages 405-412Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.diagmicrobio.2014.04.002
Keywords
Gut microbiota imbalance; Probiotics cocktail; Bacteriotherapy; Diarrhea
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Funding
- Innovation Fund for Technology-based SMEs [12C26214104321]
- National Spark Program of China [2011GA750017]
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Antibiotic-resistant probiotics may be advantageous for antibiotic-induced gut microbiota imbalance. In this article, we aimed to isolate antibiotic-resistant bacteria as potential probiotics. Feces from 3 healthy adults and 2 infants were used to isolate the antibiotic-resistant bacteria. Then we established gut microbiota imbalance mice model by antibiotics treatment and used it to assess the effect of the probiotics. Finally, we identified 8 isolates, and 6 of them were used as probiotics cocktail. Number of anaerobe, lactobacilli, and Bifidobacterium in feces were higher in the probiotic group (9.47 +/- 0.35 log(10)CFU/g, 8.74 +/- 0.18 log(10)CFU/g, 7.24 +/- 0.38 log(10)CFU/g, respectively) compared with model group (P < 0.05). Richness and diversity index of probiotic group (19.79 +/- 0.29 and 2.95 +/- 0.06, respectively) were larger than model group (P < 0.05). Diarrhea and mucosal edema had been alleviated during probiotic treatment. Our results validated that bacteriotherapy was available to treat gut microbiota imbalance. (C) 2014 Elsevier Inc. All rights reserved.
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