Journal
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
Volume 76, Issue 1, Pages 80-85Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.diagmicrobio.2013.02.001
Keywords
Carbapenemases; bla(KPC) dissemination; Wastewater
Categories
Funding
- Fundacao Apoio a Pesquisa do Estado de Sao Paulo, Brazil (FAPESP) [2009/11051-0]
- National Council for Science and Technological Development (CNPq), Ministry of Science and Technology, Brazil [307816/2009-5, 302981/2011-0]
- Sanofi-Aventis
- Thermo Fisher
- bioMerieux
Ask authors/readers for more resources
We investigated the antimicrobial resistance profile and the occurrence of Klebsiella pneumoniae carbapenemase (KPC)-producing Gram-negative rods in sewage samples obtained from a Brazilian teaching hospital and from the wastewater treatment plant (WWTP) that receives it for treatment. We identified multidrug-resistant bacteria as well as KPC-2-producing Aeromonas spp. and several Enterobacteriaceae species, including Kluyvera spp., in the hospital effluent and in different sites of the WWTP. Most isolates showed the bla(KPC-2) gene harbored on a transposon that was carried by conjugative plasmids. The presence of KPC production among Aeromonas spp., Kluyvera spp., and other Enterobacteriaceae indicates the adaptability of such isolates to aquatic environments, not only in the hospital effluent but also throughout the WWTP. Although secondary treatment seems to decrease the amount of KPC producers in sewage, multidrug-resistant isolates are continually disposed in the urban river. Thus, sewage treatment regulations are urgently needed to decelerate the evolution of antimicrobial resistance beyond hospitals. (C) 2013 Elsevier Inc. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available